ABSTRACT Background: Crinum pedunculatum R.Br. bulbs are used for the topical management of inflammation by traditional healers in the southern region of Ghana. Objectives: This study aims to assess the analgesic, anti-inflammatory, and anti-pyretic activities of different solvent extracts of Crinum pedunculatum. Methods: The analgesic, anti-inflammatory, and anti-pyretic activities of the bulb extracts of Crinum pedunculatum were determined in rats at doses of 100, […]
GC-MS analysis of Phytocomponents in the Methanol Extract of Premna latifolia Roxb
ABSTRACT Background: According to existing literature, the genus Premna has a variety of biologically active secondary metabolites, but there are few findings on phytochemical screening of P. latifolia Roxb. Methanolic leaves extract. Objectives: Phytochemical screening of methanolic leaves extract of P. latifolia was proposed for this study. Materials and Methods: UV-chamber, HPTLC instrument (CAMAG TLC Scanner), and GC-MS instrument (Perkin-Elmer GC- Clarus) were used […]
Virtual Screening of Fargesin Analogs as Candidates as Inhibitors of Aedes aegypti Sterol Carrier Protein
ABSTRACT Background: Fargesin is a natural product that was identified by our group in previous work as a potent ligand of the sterol-binding protein-2 (SCP-2) of Aedes aegypti, the mosquito that which causes the propagation of diseases such as zika, dengue, Chikungunya, and yellow fever. Objectives: propose structural analogs synthetically accessible to be evaluated by molecular docking, preserving the […]
Preliminary Assessment of Glycemic Control and Body Fat Reduction Effects of Terminalia chebula Retz. Extract on Pre-diabetic Subjects
ABSTRACT Background: Terminalia chebula Retz. (Combretaceae) is a medicinal herb using in traditional medicine worldwide and has hypoglycemic effects in animal models. Objectives: The present study was a double-blind, placebo-controlled trial designed to study the effect of T. chebula fruit water extract (TFWE) in pre-diabetic subjects. The efficacy of TFWE and placebo were compared in terms of reducing fasting blood sugar […]
Preventive Effects of Ginger Extract and Nigella sativa Oil on Anxiety and Depression Behavior in Wistar Rats Exposed to Mercuric Chloride
ABSTRACT Background: Mercuric chloride (HgCl2) is toxic to humans and animals, and usually causes systemic and nerve damage. Aim: The aim of this study is to evaluate the neuro-protective effects of two medicinal plants rich in antioxidants against mercuric chloride poisoning in Wistar rats. Materials and Methods: This is an experimental study conducted on twenty-five adult rats randomly divided into […]
Arbortristoside-A: A promising bioactive moiety from nyctanthes arbortristis linn. against hemorrhoid
ABSTRACT Background: Hemorrhoid disease is becoming a common problem in modernized society and its treatment is less developed. Although there are many plants used traditionally, proper scientific evidence is still lacking. Nyctanthes arbortristis Linn. is scientifically proved to have pharmacological activities. In this research work, an approach has been made to establish the potentiality of arbortristoside-A from N. arbortristis L. […]
Data mining and network pharmacology study on dried tangerine peel and immature tangerine peel essential oil as a treatment for liver depression and insomnia
ABSTRACT Background: With the variation of modern medical mode from “disease medicine” to “health medicine,” the traditional Chinese medicine (TCM) aromatherapy befits an important part of the exclusive health service resource intended for the prevention of diseases, rehabilitation and health care in China. Liver depression and insomnia are among the human health conditions that are apparently […]
Antifibrotic effects of lilii bulbus extract in a mouse model of bleomycin-induced pulmonary fibrosis
ABSTRACT Objectives: Lilii Bulbus (LB), a lung-moistening herbal medicine, has been used to treat the symptoms of pulmonary fibrosis, including dry cough and dyspnea. In this study, we investigated whether LB water extract (LIB) has antifibrotic effects in a mouse model of bleomycin-induced pulmonary fibrosis. Materials and Methods: The effects of LIB and its mechanisms of action were […]
Effects of retinoic acid-induced osteoporosis on pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxy stilbene-2-Ο-β-D-glucoside and β-ecdysterone in rats
ABSTRACTBackground: The compatibility of Radix Polygoni multiflori-Achyranthes (RPMA) root is a Traditional Chinese medicine pair frequently used in the clinic and has good anti-osteoporosis (OP) effects. Materials and Methods: The extract of the compatibility of RPMA root was given orally in this study. The pharmacokinetics and the distribution in the tissues of tetrahydroxystilbene glucoside and β-ecdysterone were considered by high-performance […]
Phytochemical investigation of bauhinia winitii based on alpha-glucosidase inhibitory effect and molecular docking affirmation
ABSTRACT Background: Bauhinia winitii (BW) (Fabaceae) plant revealed poor phytochemical investigation and anti-diabetic report. As one of the Bauhinia family which known with abundant flavonoids content, contrary, BW was only used for the treatment of diarrhea in Thai conservative remedy. Objectives: The aim of this study was to investigate the phytochemical constituents and anti-alpha glucosidase activity of BW. Materials and Methods: Phytochemical study […]