Month: January 2021

Pueraria candollei var. mirifica-Induced CYP1A1 and CYP1A2 expression in human choriocarcinoma bewo cells

ABSTRACT Background: The human placenta metabolizes many endogenous substances, drugs, and xenobiotics. Cytochrome P450 family 1 (CYP1) is expressed in both early- and full-term placenta. The Thai medicinal plant Pueraria candollei var. mirifica (PM) is traditionally consumed for rejuvenation and has neuroprotective, anti-osteoporotic, and antioxidant activities.  Objectives: The objective of this study was to compare the effects of PM and the CYP1A […]

Effect of plant part, extraction method, and harvest time over antioxidant yield of rubus coreanus

Pharmacognosy MagazineDOI: 10.4103/pm.pm_549_19 ABSTRACT Background: Immature fruit of Rubus coreanus, also known as “Bokbunja” in Korea, have been used as traditional medicinal plant in East-Asia. Although several studies have been conducted to the fruit composition of R. coreanus, research on the antioxidant composition of branch and leaves are limited.  Objectives: We aimed to analyze the contents of five antioxidants in leaves […]

Embelin from Embelia ribes ameliorates oxidative stress and inflammation in high-fat diet-fed obese C57BL/6 mice

Pharmacognosy MagazineDOI: 10.4103/pm.pm_77_20 Background: A safe, efficacious, and economical drug for the treatment of obesity is the need of the time. Literature published in previous years referred to embelin as a potential investigational therapeutic agent to manage obesity.  Objectives: This study was designed to isolate and characterize embelin from Embelia ribes and further to assess its role in alleviating […]

Enhancement of chlorogenic content of the eggplant fruit with eggplant hydroxycinnamoyl CoA-quinate transferase gene via novel agroinfiltration protocol

Pharmacognosy MagazineDOI: 10.4103/pm.pm_537_19 ABSTRACT Background: Eggplant (Solanum melongena L.) is rich in health-promoting phenolic acids, primarily in the chlorogenic acid. For the production of chlorogenic acid in the eggplant hydroxycinnamoyl CoA-quinate transferase (SmHQT), is a central enzyme that catalyzes the reaction to the chlorogenic acid production.  Objective: The function of SmHQT is not well determined in the eggplant fruit, […]

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